The turn of the millennia will usher in a new age of human civilization. What happens in this century will have long-lasting impacts for millennia to come as humanity reaches for the stars. The 21st century promised to be a new golden age of society. It has not turned out as expected. Instead of economic prosperity, it faced some of the worst combinations of financial and societal crises in history. Instead of scientific enlightenment, it became struck by a solid reactionary movement fueled by fear and politics against medicine and technology. Instead of a new century of unprecedented levels of peace, it has produced worse conflicts and humanitarian disasters than many in the Cold War. Drawing from the ancient Greek myth of Pandora, who inadvertently unleashed suffering upon the world despite initial intentions of curiosity and gift-giving, we can underscore the unforeseen consequences that accompany progress. Progress, while heralding remarkable benefits of technological innovations, improved healthcare, and economic development, can also bring about significant drawbacks. These include environmental degradation, social disparities, and ethical dilemmas that challenge our moral frameworks. The duality in progress highlights that with each step forward, there is often a hidden cost that must be considered. By examining progress through the lens of Pandora's Box, we are reminded to approach future developments with both optimism and caution, ensuring that the pursuit of progress does not unleash new forms of adversity upon society. Only by accepting the reality of this distressing chapter and the burdens of global citizenship can humanity, united in history and destiny, ultimately realize the promise once made of this new era.